Avaliação do grau de inflamação vascular em pacientes com síndrome metabólica

Adriana Silva Monteiro Junqueira, Luiz José Martins Romêo Filho, Camillo de Léllis Carneiro Junqueira
2009 Arquivos Brasileiros de Cardiologia  
Metabolic Syndrome (MS) is defined as a set of cardiovascular risk factors related to visceral obesity and insulin resistance that lead to an increase in general mortality, especially cardiovascular. The inflammatory markers are considered emergent risk factors and can be potentially used in the clinical stratification of cardiovascular diseases, establishing prognostic values. Objective: This study aims at evaluating which components of the MS present an increase of IL-6 and hs-CRP,
more » ... hs-CRP, identifying the marker that better expresses the degree of inflammation and which isolate component presents a higher degree of interference on the studied inflammatory markers, in order to identify other important risk factors when determining arterial inflammation. Methods: A total of 87 hypertensive, diabetic and dyslipidemic patients were selected, aged 26 to 85 years, who met the necessary criteria for the positive diagnosis of MS. The patients were assessed through 24-hour ambulatory blood pressure monitoring (ABPM) and underwent hs-CRP and IL-6 measurements, among other metabolic variables. Results: The patients that presented CRP > 0.3mg/dL showed a significant correlation (P<0.05) with abdominal perimeter >102/88 cm in 83.7%, glycemia > 110mg/dL in 88% and BMI > 30kg/m 2 in 60.5% of the studied individuals. Conclusion: We concluded that the CRP was the inflammatory marker with the highest expression regarding the studied variables, with smoking, albuminuria, previous personal history of cardiopathy, BMI, abdominal perimeter and hyperglycemia being the ones with the highest statistical significance. Interleukin-6 did not present a correlation with any of the studied variables. (Arq Bras Cardiol 2009; 93(3) : 334-339)
doi:10.1590/s0066-782x2009001000008 pmid:19936455 fatcat:j75iyt76crfkdnvhjtemhzzy2e