The synthesis of amoxicillin derivate has been done by reacting amoxicillin with 4t-butylbenzoil chloride. The products were characterized by organoleptic test, melting point determination, TLC, UV/Vis Spectrophotometry, AND FTIR Spectrophotometry. Further, the antibiotics activity test of amoxicillin derrivate against Salmonella typhi were tested by using diffusion method. This product have been characteristic such as powder, light yellow, and bite bitter. Melting point of product was 132 °C.

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... roduct was 132 °C. Rf value of product was 0.86. pH value of product amoxicillin derivate was 7.7. The results of UV wavelength scanning showed that product derivate of amoxicillin compounds had peak at 286 nm. amoxicillin derivate had peaks in 3271 cm-1 (-NH amina), 2962 cm-1 (-CH aromatik), 1633 cm-1 (-C=O keton), dan other. Further, amoxicillin derivate was unable to clear zone formed around disk paper. N-4t-Butylbenzoyl was can't be used for the treatment of thypoid fever.