Medical Mobilization and the War
Journal of the American Medical Association (JAMA)
longer time. The daily intensive use of the drug therefore means that it accumulates rapidly in the system ; in view of the fact that some of the most serious accidents develop only after several days, the question may justly be raised whether this intensive use is not exposing the patient to added risk, which should not now be taken. It is true that many serious reactions lately reported occurred immediately, indi¬ cating also that it would be wise to begin with a small dose say 0.3 gram.
... say 0.3 gram. Boiling arsphenamin is also an occasional practice. This should be discontinued. The brand "arsenobenzol" is of difficult solubility, but this brand can be safely dissolved in hot water. The more soluble brands do not stand heat well and should be dissolved in water at room temperature. In gen¬ eral, practitioners should be more than ordinarily cau¬ tious in the use of arsphenamin at the present time. We are working under great pressure in medicine as in other lines. This is not the time to be careless of risks in the intensive use of this drug or indifferent to the possibilities of its being made toxic by boiling or other incautious manipulations. MORPHIN AND REACTION TIME The announcement of a new journal, Psxchobiology} states that it is established for "the publication cf research bearing on the interconnection of mental and physiological functions. It will include in its volumes, therefore, not only investigations of what is sometimes called 'psychological physiology,' but also investigations in pharmacology, physiology, anatomy, neurology, and psychiatry in so far as the results of these investiga¬ tions have explicit bearing on problems of mental life, or mental factors are included in the essential condi¬ tions of the investigation." The first number illus¬ trates the relation of psychology to pharmacology in a research on the effect of some opium alkaloids on the psychologic reaction time.2 The effects of alcohol and alcoholic beverages on psychic functions have been investigated frequently ; some attention has likewise been paid to coffee and tea and the caffein that they contain. In connection with such commonly used drugs it is often asked whether they really stimulate in the true sense of the word, or, in refined analysis, are they merely found to depress or inhibit ? In the case of morphin alone or in combination with other opium alkaloids, Macht and Isaacs2 of John Hopkins University have found that tke answer depends on the dose used. In man, after small doses of morphin, there is generally a primary stage of stimulation or quickened reaction time ; this may or may not be fol¬ lowed by a secondary stage of depression, as indicated by narcosis and prolongation of the reaction time. After large doses of morphin, the primary stimulation stage is very short and may be overlooked, whereas the secondary or stage of depression is predominant. The small doses, which gave a distinct primary stimu-1. Psychobiology, a journal devoted to the field common to psychology and the biologic sciences, edited by Knight Dunlap, in association with