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In 1897, and again in 1899, Dr. Macleod drew attention to a new method of employing the bromides as sedatives. His method might be described as that of the massive dose, two drachms of the drug being given in half a tumbler of water every two hours (during the day) till an ounce is given. On the second day a similar amount is given in the same way, and this may suffice to induce a sleep lasting from five to nine days. During this sleep the patient is not so deeply unconscious that he cannot bedoi:10.1192/bjp.47.196.191 fatcat:r767yfblzvelvjsvxlegifpipm