The Bromide Sleep: A New Departure in the Treatment of Acute Mania. (Brit Med. Journ., Jan. 20th, 1900.) Macleod, N

Harrington Sainsbury
1901 Journal of Mental Science  
In 1897, and again in 1899, Dr. Macleod drew attention to a new method of employing the bromides as sedatives. His method might be described as that of the massive dose, two drachms of the drug being given in half a tumbler of water every two hours (during the day) till an ounce is given. On the second day a similar amount is given in the same way, and this may suffice to induce a sleep lasting from five to nine days. During this sleep the patient is not so deeply unconscious that he cannot be
more » ... that he cannot be roused to micturate, or for the bowels to act, or for the administration of food; but left to himself he would starve, and the organic functions work unnoticed. Feeding must be rigorously maintained, and a tumblerful of milk every two hours up to seven tumblerfuls will suffice to maintain nutrition. Following the sleep is a gradual return of consciousness; this takes some fourteen days, the whole treatment lasting some twenty-one to twenty-four days.
doi:10.1192/bjp.47.196.191 fatcat:r767yfblzvelvjsvxlegifpipm