mTOR signaling pathway and mTOR inhibitors in the treatment of cancer

Mehmet Küçüköner
2013 Dicle Medical Journal  
Mammalian target of rapamycin (mTOR) plays a major role in the regulation of protein translation, cell growth, and metabolism. Three basic signalling pathways that have been described as important in cancer including the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR kinase cascade, the protein kinase C (PKC) family, and the mitogen-activated protein kinase (MAPK)/Ras signalling cascades. mTOR has been defined as a key kinase acting downstream of the activation of PI3K/AKT. These pathways are
more » ... ese pathways are frequently deteriorated in cancer, and therefore mTOR inhibition is a important antitumor target. mTOR inhibitors include rapamycin (i.e. sirolimus) and its derivatives; temsirolimus, everolimus, ridaforolimus and deforolimus. mTOR inhibitors has the important potential to provide anticancer activity in many tumor types. Key words: PI3K/AKT/mTOR, mTOR inhibitors, cancer 157 Dicle Tıp Derg / Dicle Med J www.diclemedj.org Cilt / Vol 40, No 1, 156-160 Dicle Tıp Derg / Dicle Med J www.diclemedj.org Cilt / Vol 40, No 1, 156-160 KAYNAKLAR
doi:10.5798/diclemedj.0921.2013.01.0248 fatcat:gykwts7ws5g6necobv4wnyli5u