Update on Genetic Determinants of Type1 Diabetes

Philippe A Lysy
2016 Journal of Molecular and Genetic Medicine  
Type 1 diabetes (T1D) results from a progressive destruction of insulin-secreting β cells with consecutive life-long dependence to exogenous insulin. Avoidance of end-stage β-cell mass destruction through primary and secondary prevention strategies requires understanding of initial molecular events leading to insulinopenia. Although autoimmune dysregulation is predominant in T1D, environmental and genetic predisposing factors have been identified and partly account for the heterogeneity of the
more » ... terogeneity of the disease. The use of patient databases and the development of new technologies for genetic screening will help to identify at-risk individuals in the general population or in families with affected siblings. Here we discuss the latest developments in the identification of genetic determinants of T1D and their use for evaluation of disease risk. A diseaseassociated PTPN22 variant promotes systemic autoimmunity in murine models.
doi:10.4172/1747-0862.1000126 fatcat:azl7hdp6zfa6jcbdcm2nmthafq