Mesothelin and osteopontin as diagnostic and prognostic markers of malignant pleural mesothelioma in Egyptian patients undergoing pleurodesis

Fawzy M. Amany, Nagat Ali Mohamed, Reda El-Ghamry, Alaa Brik, Abdel Maged Salem, Amira Shoukry, Azza El-Sebaey
2013 Egyptian Journal of Chest Disease and Tuberculosis  
KEYWORDS Mesothelin Osteopontin Malignant pleural mesothelioma Pleurodesis Abstract Purpose: In malignant pleural mesothelioma (MPM), early assessment of disease status is important. We evaluated the role of mesothelin and osteopontin biomarkers in distinguishing MPM from benign pleural disease. We also, evaluated whether mesothelin and osteopontin were related to successful pleurodesis or not. Materials and methods: Mesothelin and osteopontin were assayed in blood and pleural fluid with
more » ... ial ELISA kits in a series of 20 patients with malignant mesothelioma and 20 patients with benign pleural effusion (10 patients with tuberculous pleural effusion and 10 patients with benign asbestos pleural effusion). Results were correlated with histological subtypes and pleurodesis outcome.
doi:10.1016/j.ejcdt.2013.04.005 fatcat:el4qkynvm5hldlt3pzloqpyn5m