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Down syndrome originally known as Mongoloid's idiocy is the most common autosomal disorder. Down syndrome (DS) can be detected by prenatal diagnosis which includes the triple marker screening test and chromosomal analysis. Methods: The study population comprised of 100 pregnant females amongst the age group of 20-45 (32.10±4.86) years. Triple Marker Test was done followed by amniocentesis or CVS with karyotyping or FISH. Results: Risk of <1:250 was considered high risk whereas ≥1:250 wasdoi:10.18203/2320-6012.ijrms20164216 fatcat:covgnvchtrcfnpprdburuxja2a