HIV-1 evolution, drug resistance, and host genetics: The Indian scenario

U. Shankarkumar, Aruna Pawar, Kanjaksha Ghosh
2009 Virus Adaptation and Treatment  
A regimen with varied side effects and compliance is of paramount importance to prevent viral drug resistance. Most of the drug-resistance studies, as well as interpretation algorithms, are based on sequence data from HIV-1 subtype B viruses. Increased resistance to antiretroviral drugs leads to poor prognosis by restricting treatment options. Due to suboptimal adherence to antiretroviral therapy there is an emergence of drug-resistant HIV-1 strains. The other factors responsible for this viral
more » ... ible for this viral evolution are antiretroviral drug types and host genetics, especially major histocompatibility complex (MHC). Both primary and secondary drug resistances occur due to mutations in specifi c epitopes of viral protein regions which may infl uence the T cell recognition by immune system through MHC Class I and class II alleles. Mutations in viral epitopes enable the virus to escape the immune system. New drugs under clinical trials are being added but their exorbitant costs limit their access in developing countries. Thus the environmental consequences and, the impact of both viral and host genetic variations on the therapy in persons infected with HIV-1 clade C from India need to be determined.
doi:10.2147/vaat.s4974 fatcat:q7phxikvenhhzgwpgist7erqre