Evaluation of certain bioactive compounds using in ovo diabetic model

Srinivasan K
2018 Figshare  
Mammalian models are frequently used for drug research and delivery systems. However, valid mammalianmodels are expensive, time consuming and not easy to set up and evaluate. Furthermore, they are often linkedwith ethical and legal aspects. Many micro, macro nutrients and other photochemical from food materialsare found to possess many desirable health benefits. A large number of studies involving animals havebeen carried out to explore these beneficial properties. As an alternative, chick
more » ... rnative, chick embryo developed throughincubation of fertile chicken eggs has been used as a novel system to develop suitable models for biochemicaland neutraceutical research. The in ovo technique is accepted as an alternative to traditional mammalianmodels and this can be suitably used in our routine biochemical tests, wherever the animal trials are notfeasible. In view of the above, the development and evaluation of certain bioactive components using in ovotechnique as a diabetic model was carried out in our laboratory. Bixin decreased significantly the plasmaglucose, triglycerides, cholesterol, urea, creatinine and blood urea nitrogen, while liver glycogen levels intreated diabetic chick embryos increased when compared to control diabetic chick embryos.
doi:10.6084/m9.figshare.6071699 fatcat:tktiwievejdl5b3mcyqizidyie