Comparing Acute Aerobic vs. Resistance Exercise (CAARE) in young and older adults: Design and methods of a randomized acute exercise trial on the immune system [post]

2020 unpublished
It is well accepted that exercise has numerous health benefits, including reducing the risk of developing cardiometabolic diseases and supporting a healthy immune system. Although these benefits are widely recognized, variations in the exercise response still exist. The aim of this study is to explore the variations that may be partially explained by participant age, physical activity status, and/or mode of exercise. Methods: The CAARE (Comparing Acute Aerobic vs. Resistance Exercise) study is
more » ... Exercise) study is a randomized crossover design trial. Participants are young (18-30 years) or older (55-75 years), and within each age group are either physically active or inactive. All participants complete two acute exercise sessions of similar intensity and duration: a resistance training bout and a treadmill exercise bout. Blood is collected before exercise (PRE), immediately after exercise (POST), and after one hour of recovery (RECOV). Fresh blood is used for flow cytometry analyses to phenotype immune cells. Serum is stored for future analyses. The primary outcome variables are monocyte and T-cell phenotype. Discussion: CAARE is the first study to compare the immune cell response to acute exercise when including age, physical activity status, and mode of exercise. Clinical trial registration: This research study was registered at clinicaltrials.gov NCT03794050 in January 4, 2019. https://clinicaltrials.gov/ct2/show/NCT03794050
doi:10.21203/rs.3.rs-15250/v1 fatcat:d2mvec5kazdxvfhfb2vr4zwkhq