Central position of the human histo (blood) group O(H) and phenotype-determining enzymes in growth and infectious disease

Peter Arend
2017 Figshare  
Development of the human non-O blood groups is associated with the impaired formation of adaptive and innate immunoglobulin specificities due to clonal selection and phenotypic, glycosidic accommodation of plasma proteins, while compared with individuals with blood group O(H), individuals with blood group A have a significantly higher risk of developing certain types of cancer and exhibit strong susceptibility to malaria tropica or infection by Plasmodium falciparum. The phenotype-determining
more » ... otype-determining glycotransferase(s) from blood group A, affecting the levels of anti-A/Tn cross-reactive immunoglobulins, might also complete adhesion and entry of the parasite to host cells via heterologous O-GalNAc glycosylation of the parasite's serine repeat antigen (SERA). In contrast, human blood group O(H), which lacks this enzyme, is currently discussed to have a survival advantage of the overall risk of developing cancer and rarely develops life-threatening infection by evolutionary selective malaria strains. In fact, blood group O(H) has survived as the most common blood group worldwide and thereby stressing its central position in the evolution.
doi:10.6084/m9.figshare.4714618.v263 fatcat:yv3malwwurfc7ghzkqdofvwhbq