Patterns of variation influencing antipsychotic treatment outcomes in South African first-episode schizophrenia patients

Britt I Drogemöller, Dana JH Niehaus, Bonginkosi Chiliza, Lize van der Merwe, Laila Asmal, Anil K Malhotra, Galen EB Wright, Robin Emsley, Louise Warnich
2014 Pharmacogenomics (London)  
i Declaration By submitting this dissertation electronically, I declare that the entirety of the work contained therein is my own, original work, that I am the sole author thereof (save to the extent explicitly otherwise stated), that reproduction and publication thereof by Stellenbosch University will not infringe any third party rights and that I have not previously in its entirety or in part submitted it for obtaining any qualification. This dissertation includes one original paper published
more » ... nal paper published in a peer-reviewed journal, one original paper that is in press in a peer-reviewed journal, one publication that is currently under peer-review and one unpublished publication. The development and writing of the papers (published and unpublished) were the principal responsibility of myself and, for each of the cases where this is not the case, a declaration is included in the dissertation indicating the nature and extent of the contributions of co-authors. Abstract Schizophrenia is a debilitating disorder that occurs the world over. Although antipsychotics are largely effective in treating the positive symptoms of schizophrenia, the outcomes are non-optimal in many patients. As antipsychotic treatment response has been shown to be heritable, it is expected that the implementation of antipsychotic pharmacogenomics should aid in the optimization of antipsychotic treatments, however to date clinically applicable results are limited. Therefore this study utilized exome sequencing in a cohort of well characterized first episode schizophrenia patients to identify the genetic factors contributing to antipsychotic treatment response. Stellenbosch University iv antipsigotiese farmakogenetiese studies bevestig nie, maar ook nuwe gene en variante wat betrokke is in antipsigotiese reaksie geïdentifiseer. Hierdie resultate sal hopelik ons begrip van die onderliggende biologiese faktore wat antipsigotiese behandelingsrespons beïnvloed verbeter en uiteindelik ook met die optimalisering van behandeling help. Stellenbosch University v
doi:10.2217/pgs.13.218 pmid:24444409 fatcat:upkl4aunuzhmfixftu3rbrlybi