Referee report. For: Case Report: Secondary bilateral parkinsonism and dystonia treated with dronabinol [version 1; peer review: 1 approved with reservations]

Jose Luis Lopez-Sendon Moreno
Drug abuse may damage basal ganglia that are essential for planning and execution of movements. We report a 38-year old patient with ischemic lesions of the basal ganglia presenting with bilateral painful dystonia and parkinsonism caused by polyintoxication. Dronabinol resulted in improvement of pain and gait disturbance, suggesting a novel therapeutic strategy in these challenging patients.
doi:10.5256/f1000research.29232.r71804 fatcat:r6nu5ewm5be3dibjhedpo6ipwa