A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf
.
ZAK inhibitor PLX4720 promotes extrusion of transformed cells via cell competition
2020
iScience
Previous studies have revealed that, at the initial step of carcinogenesis, transformed cells are often eliminated from epithelia via cell competition with the surrounding normal cells. In this study, we performed cell competition-based high-throughput screening for chemical compounds using cultured epithelial cells and confocal microscopy. PLX4720 was identified as a hit compound that promoted apical extrusion of RasV12-transformed cells surrounded by normal epithelial cells.
doi:10.1016/j.isci.2020.101327
pmid:32688284
pmcid:PMC7371749
fatcat:moabz2r245fclczntvrz42yzk4