DRUG ERUPTIONS FROM THE CLINICAL ASPECT

FRED WISE
1922 Archives of Dermatology and Syphilology  
Whoever has read Prince A. Morrow's 1 monograph on drug eruptions will surely sympathize with us in our effort to present the subject of "Drug Eruptions from the Clinical Aspect" with the greatest possible expedition ; with Morrow's work before us, we feel that little more can be said. The eruptions of his day are, with a few additional examples, those of today. The best course to follow, it seems to us, is to forbear from burdening you with a reiteration of the well-known cutaneous
more » ... taneous manifestations resulting from the use and abuse of the older drugs, and to devote what time and space is at our disposal to a consideration of eruptions provoked by the recent medicaments. Among the latter are included such widely used drugs as barbital, medinal, adalin, bromural, phenobarbital (luminal), cinchophen, pyramidon, melubrin, acetylsalicylic acid, hexamethylenamin, phenolphthalein and the various arsphenamins. DEFINITION As used today, the term "drug eruptions" is synonymous with dermatitis medicamentosa; that is, eruptions resulting from the introduction into the body of drugs which undergo absorption and elimina¬ tion. The older definition of the term "drug eruption" embraces a much broader field and is interpreted by Morrow in this sentence : "In the proper signification of the term, drug eruptions embrace all con¬ gestive and inflammatory changes in the skin caused by the external and internal use of drugs."2 Today, the term dermatitis venenata is used to designate eruptions resulting from contact of irritant materials with the skin. CLASSIFICATION What Morrow said with regard to classification thirty-five years ago still holds good at the present time ; namely, that "a classification based
doi:10.1001/archderm.1922.02360050015002 fatcat:oyurmsfvhrcmzducbg5sn4gvcy