Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency

R. Arujun, T. Kumanan, V. Sujanitha, T. Sooriyakumar, R. M. U. K. B. Ratnayake, A. Anuruththan
2019 Sri Lanka Journal of Medicine  
Glucose 6 phosphate dehydrogenase (G6PD) is a housekeeping enzyme critical in the redox metabolism. In red blood cells, it is the only source of nicotinamide adenine dinucleotide phosphate hydrogen(NADPH) that acts directly and, via glutathione, defends these cells against oxidative stress. Dengue infection,like other infections, can trigger intravascular haemolysis in G6PD deficiency patients. We have reported a 17 year old boy with G6PD deficiency who presented with dengue fever which was
more » ... fever which was complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis.
doi:10.4038/sljm.v28i2.127 fatcat:nspu2o45uzdtncuxtwotlfdatq