Role of T Follicular Helper (Tfh) Cells Plasticity in Autoimmune Thyroiditis among Hepatitis C Virus Infection

Helal F Hetta
2017 Gastroenterology & Hepatology Open Access  
T follicular helper (Tfh) cells are a new subset of CD4+ T cells located in tonsils and circulating in the blood. Thf cells are required for maintenance of the germinal center reactions and generation of humoral immunity via their expression of many molecules as CD40 ligand, IL-21, IL-4, and others. Tfh cells provide the help to B-cells to differentiate to plasma cells. It has a unique phenotype CXCR5+ and express a master regulator BCL-6.
doi:10.15406/ghoa.2017.06.00214 fatcat:on2pattvgbhvhn4svnuodumn7a