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We studied the viability of high-performance liquid chromatography and mass spectrometry (LC/ MS) as a selective and sensitive analytical method for measuring blood concentrations of the local anesthetic ropivacaine. Ropivacaine was effectively separated using a reverse-phase column and monitored at 275 m/z ion. The LC/MS method allowed measurement of concentrations of ropivacaine of lower than 75 ng/mL. The standard curve was linear and in the range of < 1.5 μg/mL. Recovery of ropivacaine indoi:10.2220/biomedres.30.319 pmid:20051639 fatcat:d2snygzlknbkbalzkatf5pzs5i