Influence of Helicobacter pylori genetic type on gastroesophageal acid reflux disease in children and teenagers
Artykuł oryginlny Wpływ typu genetycznego Helicobacter pylori na występowanie choroby refluksowej przełyku u dzieci i młodzieży

Monika Parzęcka, Anna Szaflarska-Popławska, Grażyna Mierzwa, Marta Gorzkiewicz, Sylwia Łuczak, Tomasz Grzybowski, Mieczysława Czerwionka-Szaflarska
2010 Gastroenterology Review  
The role of Helicobacter pylori (H. pylori) infection in pathogenesis of gastroesophageal reflux disease (GERD) remains controversial. It seems that the genotype of H. pylori influences that dependence. Aim: To assess the significance of H. pylori genotype in gastroesophageal reflux (GER) in children and teenagers. Material and methods: Hundred and one children in whom endoscopy of the upper part of the gastrointestinal tract was performed and H. pylori infection was demonstrated in
more » ... ated in histopathological and/or urease test and urea breath test. Helicobacter pylori identification was performed using the PCR method to determine the genetic type of CagA and VacA. Triple-drug eradication therapy was introduced. pH-metric examination was performed before and after treatment. Results: Infection with type I strain was found in 32.7% of patients, type II in 67.3%. Concerning the group of patients infected with type I H. pylori, GER was found in 57.6% of patients, while 45.6% infected with type II H. pylori suffered from GER. It was induced de novo in 15% of patients in the group of patients infected with type I and in 15% of cases was removed after eradication. Change concerning GER intensity degree did not occur in 70% of patients. Gastroesophageal reflux was induced de novo in the group of patients infected with type II H. pylori in 12.8% of cases and GER was removed Influence of Helicobacter pylori genetic type on gastroesophageal acid reflux disease in children and teenagers Wpływ typu genetycznego Helicobacter pylori na występowanie choroby refluksowej przełyku u dzieci i młodzieży
doi:10.5114/pg.2010.14140 fatcat:2p4x7isizvcjfot7wx4uuylbvy