GOOD CORRELATION BETWEEN TWO DIFFERENT AUTOMATED FACTOR XIII ASSAYS AND PRACTICAL RECOMMENDATIONS

Suryati Hussin, Zamzuri Idris, Wan Zaidah Abdullah
2017 Jurnal Teknologi  
Coagulation factor XIII (FXIII) can be quantitatively measured by using modern automated coagulation analyzers. It was uncertained whether different methods of FXIII quantitative measurement are correlated. Two different analytical methods were used for comparison in this study. This study selected a neurosurgical patient population for FXIII measurement, expecting a wide spectrum of results from haemostatic changes in vivo. A correlation study between FXIII activity (Berichrom F XIII, Dade
more » ... om F XIII, Dade Behring Marburg GmbH) and FXIII antigen assay (HemosIL™, Instrumentation Laboratory Company, Milano Italy) was performed using two different automated coagulation analyzers and test principles. FXIII assays using these two methods were performed on blood specimen from 84 patients taken pre and post neurosurgical procedures. A total of one hundred and thirty eight blood samples were included in this correlation study. There was a significant mean different of FXIII antigen levels pre and post intracranial surgery (p< 0.05). A significant, positive and good correlation between FXIII antigen and activity assays were documented by both methods, r = 0.86, and p<0.001. FXIII antigens are correlated with FXIII activity assays indicating the reliability and robustness of both methods for quantitation of FXIII in the blood. These two methods are recommended for both diagnostic and research purposes.
doi:10.11113/jt.v79.10840 fatcat:e4k4dbgb7fdjrnzp4zp26mp6ma