Effect of combined oral contraceptive pills on some haemostatic parameters

Muna A. Kashmoola, Ahmed J. AL-Husaynee
2007 Annals of the College of Medicine Mosul  
Objective: To assess our local status of markers of coagulation in response to combined oral contraceptive (COC) pill. Methods: A prospective clinico-haematological study was carried out in private lab. Forty non smoker women on (COC) pill ( Levonorgestrel 0.25 mg and ethinyl estradiol 0.05mg) for 3 months and more; their ages ranging between thirty and thirty five with a control group of 40 women were studied during a period of 6 months starting from August 2006. Most important haemostaic
more » ... ant haemostaic parameters including platelet count (PC) Prothrombin time (PT) and activated partial thromboplastin time (APTT), Fibrinogen and D-dimer were done for them. Results: There was a significant increase in the mean values of (PC), fibrinogen with (P <0.05, <0.05) respectively, while the PT and APTT were significantly reduced with (P <0.05, <0.05) respectively. D-dimer was significantly positive in users than non users (P<0.001). Conclusion: there was some degree of pro-coagulant activity in women on COC and such females need monitoring of haemostatic parameters. ‫اﻟﺨﻼﺻﺔ‬ : ‫اﻟ‬ ‫ﻣﻨﻊ‬ ‫ﺣﺒﻮب‬ ‫ﻳﺴﺘﻌﻤﻠﻦ‬ ‫اﻟﻼﺗﻲ‬ ‫اﻟﻨﺴﺎء‬ ‫ﻋﻨﺪ‬ ‫اﻟﺘﺠﻠﻂ‬ ‫ﻣﻌﺎﻳﻴﺮ‬ ‫ﺑﻌﺾ‬ ‫ﻋﻦ‬ ‫ﻟﻠﺘﺤﺮي‬ ‫اﻻﺳﺘﺮوﺟﻴ‬ ‫ﻣﺮآﺒﺎت‬ ‫ﻣﻦ‬ ‫اﻟﻤﻜﻮن‬ ‫ﺤﻤﻞ‬ ‫ﻦ،‬ ‫واﻟﺒﺮوﺟﺴﺘﻴﺮون‬ ( ‫اﻟﻌﻤﻞ‬ ‫ﻃﺮﻳﻘﺔ‬ : ‫دراﺳﺔ‬ ‫ﻣﺨﺘﺒﺮﻳﻪ‬ ‫ﻣﺴﺘﻘﺒﻠﻴﺔ‬ ‫ﺧﺎص‬ ‫ﻣﺨﺘﺒﺮ‬ ‫ﻓﻲ‬ ‫اﻟﺪراﺳﺔ‬ ‫ﻧﻔﺬت‬ ‫ﻷﻣﺮاض‬ ‫اﻟﺪم‬ ‫ﺳﺘﺔ‬ ‫وﻟﻤﺪة‬ ‫أﺷﻬﺮ‬ ‫ﻣﻦ‬ ‫اﻋﺘﺒﺎرا‬ ‫ﺁب‬ ٢٠٠٦ ‫م‬ . ‫وﺷﻤﻠﺖ‬ ‫ﻣ‬ ‫ﻋﻠﻰ‬ ‫اﻟﺪراﺳﺔ‬ ‫وﻋﺪد‬ ‫اﻟﻤﺮآﺒﺔ‬ ‫اﻟﺤﻤﻞ‬ ‫ﻣﻨﻊ‬ ‫ﺣﺒﻮب‬ ‫ﻳﺴﺘﻌﻤﻠﻦ‬ ‫اﻟﻼﺗﻲ‬ ‫اﻟﻨﺴﺎء‬ ‫ﺠﻤﻮﻋﺔ‬ ّ ‫هﻦ‬ ٤٠ ‫ﻋﺪدهﺎ‬ ‫ﺿﺎﺑﻄﺔ‬ ‫ﻣﺠﻤﻮﻋﺔ‬ ‫ﻣﻊ‬ ٤٠ ‫اﻣﺮأة‬ ‫ﺗ‬ ‫وﻟﻘﺪ‬ ‫ﻢ‬ ‫إﺟﺮاء‬ ‫ﻋﻠﻴﻬﻦ‬ ‫اﻟﺘﺎﻟﻴﺔ‬ ‫اﻻﺧﺘﺒﺎرات‬ : ‫وﺗﺸﻤﻞ‬ ‫اﻟﺪم‬ ‫ﺗﺠﻠﻂ‬ ‫اﺧﺘﺒﺎر‬ ( ‫اﻟﺒﺮوﺛﺮوﻣ‬ ‫زﻣﻦ‬ ‫ﻴ‬ ‫زﻣﻦ‬ ‫ﺒﻴﻦ،‬ ‫اﻟ‬ ‫ﻣﻮﻟﺪ‬ ‫ﻗﻴﺎس‬ ، ‫اﻟﻤﻔﻌﻞ‬ ‫اﻟﺠﺰﺋﻲ‬ ‫اﻟﺜﺮوﻣﺒﻮﺑﻼﺳﻴﻦ‬ ‫ﻠ‬ ‫د‬ ‫واﺧﺘﺒﺎر‬ ‫ﻴﻔﻴﻦ‬ . ‫ﻓ‬ ‫اﻟﻤﺰدوج‬ ‫اﻟﺪم‬ ‫ﺑﻼزﻣﺎ‬ ‫ﻲ‬ ) ‫ﺑﺎﻹﺿﺎﻓﺔ‬ ‫إﻟﻰ‬ ‫ﻗﻴﺎس‬ ‫أﻋﺪاد‬ ‫اﻟﺪﻣﻮﻳﺔ‬ ‫اﻟﺼﻔﻴﺤﺎت‬ . ‫اﻟﻨﺘﺎﺋﺞ‬ : ‫هﻨﺎ‬ ‫اﻟﻠﻴ‬ ‫ﻣﻮﻟﺪ‬ ‫وﻣﻘﺪار‬ ‫اﻟﺪﻣﻮﻳﺔ‬ ‫اﻟﺼﻔﻴﺤﺎت‬ ‫ﻋﺪد‬ ‫ﻓﻲ‬ ‫ارﺗﻔﺎع‬ ‫ك‬ ‫ﻔ‬ ‫ﻟ‬ ‫اﻟﻤﺴﺘﻌﻤﻼت‬ ‫اﻟﻨﺴﺎء‬ ‫ﻣﺠﻤﻮﻋﺔ‬ ‫ﻋﻨﺪ‬ ‫ﻴﻦ‬ ‫ﻣﻨﻊ‬ ‫ﺤﺒﻮب‬ ‫وﺟﺪ‬ ‫آﻤﺎ‬ ‫اﻟﻀﺎﺑﻄﺔ‬ ‫اﻟﻤﺠﻤﻮﻋﺔ‬ ‫ﻣﻊ‬ ‫ﻣﻘﺎرﻧﺔ‬ ‫اﻟﺤﻤﻞ‬ ‫أن‬ ‫اﻟﻤﻔﻌ‬ ‫اﻟﺠﺰﺋﻲ‬ ‫اﻟﺜﺮوﻣﺒﻮﻻﺑﻴﻦ‬ ‫وزﻣﻦ‬ ‫اﻟﺒﺮوﺛﺮوﻣﻴﺒﻴﻦ‬ ‫زﻣﻦ‬ ‫آﺎﻧﺎ‬ ‫ﻞ‬ ‫اﻟﻨﺴﺎء‬ ‫ﻋﻨﺪ‬ ‫ﻗﺼﻴﺮﻳﻦ‬ ‫ﻳﺴﺘﻌﻤﻠﻦ‬ ‫اﻟﻠﻮاﺗﻲ‬ ‫وﺟﺪ‬ ‫آﻤﺎ‬ ، ‫اﻟﻀﺎﺑﻄﺔ‬ ‫اﻟﻤﺠﻤﻮﻋﺔ‬ ‫ﻣﻊ‬ ‫ﻣﻘﺎرﻧﺔ‬ ‫اﻟﺤﻤﻞ‬ ‫ﻣﻨﻊ‬ ‫ﺣﺒﻮب‬ ‫أن‬ ‫د‬ ‫اﺧﺘﺒﺎر‬ . ‫اﻟﻨﺴﺎء‬ ‫ﻧﻔﺲ‬ ‫ﻋﻨﺪ‬ ‫ﻋﺎﻟﻴﺔ‬ ‫ﺑﻨﺴﺒﺔ‬ ‫ﻣﻮﺟﺒﺎ‬ ‫آﺎن‬ ‫اﻟﻤﺰدوج‬ . ‫اﻻﺳﺘﻨﺘﺎج‬ : ‫اﻟﺤﻤﻞ‬ ‫ﻣﻨﻊ‬ ‫ﺣﺒﻮب‬ ‫ﻳﺴﺘﻌﻤﻠﻦ‬ ‫اﻟﻼﺗﻲ‬ ‫اﻟﻨﺴﺎء‬ ‫ﻓﻲ‬ ‫اﻟﺘﺠﻠﻂ‬ ‫ﻗﺒﻞ‬ ‫ﻣﺎ‬ ‫ﻓﻌﺎﻟﻴﺎت‬ ‫ﻣﻦ‬ ‫اﻟﺪرﺟﺎت‬ ‫ﺑﻌﺾ‬ ‫هﻨﺎك‬ ‫آﺎن‬ ‫ﻟﻘﺪ‬ ‫اﻟﺤ‬ ‫ﻋﻠﻰ‬ ‫ﺎوﻳﺔ‬ ) ‫واﻟﺒﺮوﺟﺴﺘﻴﺮون‬ ‫اﻻﺳﺘﺮوﺟﻴﻦ‬ ( ‫اﻟﻨﺴﺎء‬ ‫هﺆﻻء‬ ‫وﻣﺜﻞ‬ ‫ﺑﺤﺎﺟﺔ‬ ‫إﻟﻰ‬ ‫ﺑﺼﻮرة‬ ‫اﻟﺘﺠﻠﻂ‬ ‫ﻓﺤﻮﺻﺎت‬ ‫ﻣﺮاﻗﺒﺔ‬ ‫ﻣﻨﻈﻤﺔ‬ .
doi:10.33899/mmed.2007.8834 fatcat:uma4rodi3neadfc663djxprdvm