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The aim of the study was to determine the role of endothelial dysfunction (ED) in the pathogenesis of diabetic nephropathy (DN) in patients with diabetes mellitus (DM) 1 and 2 type with a severe course (state of decompensation). DN was manifested by a decrease in GFR and urinary syndrome. In patients with diabetes, depending on the glomerular filtration rate (GFR), ED was estimated by the number of circulating desquamation endothelial cells (CECs) with the simultaneous determination of NO 2 anddoi:10.15407/fz64.02.034 fatcat:ehduf2dckfcubgwzoeai6drzlm