Warty gastric cancer with polypoid metastases to the gallbladder and urinary bladder

Kazuo Kato, Mutsushi Matsuyama, Seiichi Goto, Suzuko Moritani, Kazuhiro Sentani, Makoto Kuroda
2013 Gastrointestinal Cancer : Targets and Therapy  
An 80-year-old man had severe lumbago that was diagnosed as multiple myeloma. He was treated with melphalan, prednisone, and zoledronic acid, with a good response. However, he had severe anemia, and endoscopic examination revealed gastric cancer. He died 3 months later. Autopsy revealed verrucous gastric cancer consisting of numerous polypoid mucosal excrescences that had metastasized to the gallbladder and urinary bladder, showing similar polypoid mucosal lesions. The cancer consisted of
more » ... consisted of poorly differentiated cells (about 85%) and signet ring cells (15%) in the stomach. The cancerous tissue was not associated with a desmoplastic reaction, and the signet ring cells showed a positive reaction to cytokeratin 7 and regenerating islet-derived family member 4 antibodies. The cancer cells had a propensity to proliferate on the mucosal surface of the stomach, gallbladder, and urinary bladder.
doi:10.2147/gictt.s51392 fatcat:k4isttnxs5eifowykvkpgs7fii