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The morphology and function of resident macrophages in the muscle layer and in the subserosa of the gastrointestinal tract are described. FITC-dextran injected via the tail vein of a mouse or rat demonstrated a regular arrangement of macrophages on a whole mount preparation of the muscle layer. Electron microscopy revealed inactive phagocytosis under normal conditions. After a 4-8 hr incubation of rat ileal muscle with lipopolysaccharide (LPS) to investigate its effect on muscle contraction,doi:10.1267/ahc.34.219 fatcat:66qgblywfrhohafqcmyffkntke