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A F420-dependent single domain chemogenetic tool for protein de-dimerization
Protein-protein interactions (PPIs) mediate many fundamental cellular processes and their control through optically or chemically responsive protein domains has a profound impact on basic research and some clinical applications. Most available chemogenetic methods induce the association, i.e., dimerization or oligomerization, of target proteins, and the few available dissociation approaches either break large oligomeric protein clusters or heteromeric complexes. Here, we have exploited thedoi:10.1101/2022.11.07.515376 fatcat:cullmwefn5bi5a4cye3z4pdvzm