Relationship between Three-year Survival and Functional Outcome at Discharge from Acute-care Hospitals in Each Subtype of First-ever Ischemic Stroke Patients

Yutaka Suto, Hisanori Kowa, Hiroyuki Nakayasu, Etsuko Awaki, Jun Saito, Yoshito Irizawa, Kenji Nakashima
2011 Internal medicine (Tokyo. 1992)  
We studied the relationship between survival prognosis and the functional outcome at discharge from acute-care hospitals in each subtype of ischemic stroke patients. Methods A total of 853 consecutive patients with first-ever ischemic stroke, recruited from December 1999 to November 2002, were followed for 725.8 ± 430.0 days. Functional outcome was scored using the modified Rankin scale (mRS). Survival analysis was performed using Kaplan-Meier curves, log rank test, and Cox regression model.
more » ... egression model. Results The respective mortality of the groups with mRS scores of 0-2, 3, 4, and 5 were 13.1%, 25.0%, 47.2% (p<0.05), and 74.0% (p<0.05) in cardioembolic infarction (CEI) patients; 11.3%, 6.9%, 5.6%, and 46.7% (p<0.05) in atherothrombotic infarction (ATI) patients; 8.5%, 5.6%, 11.1%, and 0% (no patient) in lacunar infarction (LACI) patients; and 2.6%, 3.0%, 23.3% (p<0.05), and 28.9% (p<0.05) in infarction of unknown cause (IUC) patients. Multi-variate analysis showed that the mRS score was a significant predictive factor for death in CEI patients, and tended to be a predictive factor for death in ATI patients, or IUC patients. Conclusion Functional outcome at discharge from acute-care hospitals may predict the survival prognosis of each subtype of ischemic stroke.
doi:10.2169/internalmedicine.50.4498 pmid:21720056 fatcat:4lkck64mhrhufep5echhjcd3ii