Extracellular Vesicles in Feto–Maternal Crosstalk and Pregnancy Disorders

Danilo Buca, Giuseppina Bologna, Alice D'Amico, Sara Cugini, Francesca Musca, Melania Febbo, Dolores D'Arcangelo, Davide Buca, Pasquale Simeone, Marco Liberati, Ester Vitacolonna, Sebastiano Miscia (+2 others)
2020 International Journal of Molecular Sciences  
Extracellular vesicles (EVs) actively participate in inter-cellular crosstalk and have progressively emerged as key players of organized communities of cells within multicellular organisms in health and disease. For these reasons, EVs are attracting the attention of many investigators across different biomedical fields. In this scenario, the possibility to study specific placental-derived EVs in the maternal peripheral blood may open novel perspectives in the development of new early biomarkers
more » ... ew early biomarkers for major obstetric pathological conditions. Here we reviewed the involvement of EVs in feto–maternal crosstalk mechanisms, both in physiological and pathological conditions (preeclampsia, fetal growth restriction, preterm labor, gestational diabetes mellitus), also underlining the usefulness of EV characterization in maternal–fetal medicine.
doi:10.3390/ijms21062120 pmid:32204473 fatcat:c7ilwc6vm5e3fmqqfsy4rck4ky