Difusión de H. influenzae tipo B (HI B) en contactos intrafamiliares de niños con infecciones sistémicas por este agente

Olivia Trucco A, Valeria Prado J, José Cofre G, Jorge Vergara C, Maria Teresa Siri A, Walter Ledermann D, Mónica Córdova C, Mario Portilla F
1988 Revista chilena de pediatría  
The high spreading rate of Haemophilus influenzae serotype b (Hi b) infections in children has been already established. Rifampin prophylaxis is recommended in household contacts under 4 years of age. To define the local epidemic logical situation, 31 patients with invasive Hi b disease from two pediatric hospitals of Santiago Chile were studied (24 had meningitis, 3 facial cellulitis, 1 necrotic pneumoniae and 3 pleuropneumonia, one of them with pericarditis), looking for pharingeal carriers
more » ... aringeal carriers of Hi b among household contacts: 18% of children and 5.9% of adults contacts were colonized with the microorganism. Secondary disease was also detected in one household contact aged 7 months. Carriers were treated with oral rifampin 20 mg/kg per day (maximun dose 600 mg per day) during 4 days, which resulted in erradication of the carrier state in all cases. Twelve percent of Hi b strains were ampiciUinresistant and 4% showed ampicillin-chloramphenicol combined resistance among index cases. All strains isolated from carriers were susceptible to both drugs. (
doi:10.4067/s0370-41061988000500005 fatcat:okkimfvc6vaufe6qta743fl364