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Introduction This study was performed with the aim of detecting the interaction between cartilaginous and bone tissues in the process of mandible morphogenesis in human embryos. Material and Methods Whole-mount skeletal preparations, stained with Alcian blue and Alizarin red, as well as serial histological sections impregnated with silver and stained with hematoxylin and eosin were studied. A total of 48 human embryos/fetuses from 5 to 29 weeks of age were used. Results In the mandible anlage,doi:10.1055/s-0039-1685456 fatcat:lxgrntocevdvvhoxverywwwdci