The Effects of 8-Week Endurance Training on Prostatic Autophagy and Benign Prostatic Hyperplasia of Rats

Dong-Won Lee, Yong-Sik Hong, Sung-Hee Oh, Yoo-Hyun Lee, Jeong-Sun Ju
2019 Exercise Science  
PURPOSE: Benign prostatic hyperplasia (BPH) is a typical male adult disease in which the prostate is enlarged but not cancerous. Autophagy is a catabolic process of cellular constituents and a mechanism for cellular homeostasis of tissues. Currently, it is not established whether BPH is linked to autophagy or not and whether endurance exercise training, an autophagy activator, can ameliorate its disease symptoms. Therefore, the purpose of this study was to investigate whether BPH is closely
more » ... BPH is closely related with autophagy dysregulation and induced autophagy by exercise training can relieve BPH. METHODS: Forty-eight male wild-type SD rats (10-week old) were randomly divided into 4 groups: Sham, BPH-sedentary, BPH-exercise, and BPH-finasteride. For BPD induction, rats were castrated and testosterone (3 mg/kg/day) were administered daily for 2 months. During this period, rats performed five daily bouts of 25-minute treadmill running exercise per week or daily treated with finasteride dissolved in corn oil (10 mg/kg) by oral gavage for 8 weeks. Prostate weight, autophagy flux, serum and prostate levels of androgens and inflammatory factors were analyzed. The results were analyzed with one-way ANOVA. RESULTS: In BPH rats, the ratio of prostate weight/body weight was significantly elevated, but autophagy flux was significantly decreased (p<.05). Eight-week exercise training failed to reduce the ratio and to increase autophagy flux in the prostate of BPH rats. However, 8-week running training significantly decreased the levels of DHT and proinflammatory factors (IL-1β and IL-6) in the serum and the prostate of BPH rats (p<.05). CONCLUSIONS: This current study suggests that endurance exercise training may be beneficial for BPH not through the mechanisms involved in autophagy regulation but through alleviating hormonal and inflammatory factors. 선 요도가 좁아지거나 폐쇄되어 다양한 배뇨와 관련된 증상을 일으킨 다[1]. 60세 이후의 약 50%의 남성이 양성전립선비대증이 나타나며 양 성전립선비대증 발병률은 연령 증가와 비례하여 증가된다[2]. 양성전 립선비대증 발병의 원인은 아직 명확하게 알려져 있지 않지만 호르몬 의 불균형(androgen, estrogen), 전립선의 간질(stromal)과 상질의(epithelial) 성장인자들(growth factors)의 과잉발현, 사이토카인과 스테로 이드 호르몬 등이 원인으로 알려져 있다. 그리고 나이, 가족력, 인종, 당 뇨, 관상동맥질환, 고혈압 등과 같은 만성질환, 흡연 등이 연관되어 있
doi:10.15857/ksep.2019.28.3.270 fatcat:firhcyw2cba5pmozpnsf4n4fsu