Recent Progress in Physiology
Boston Medical and Surgical Journal
will generally be found to attend any considerable hypertrophy of the liver, when the substance of the organ remains otherwise normal. The case is one of interest as illustrating the declaration that " the spleen is the birthplace of the white and the burial ground of the red corpuscles," and also as showing the chronic, steadily progressive course of malarial blood-poisoning, terminating in its destruction, decomposition, and death from haemorrhage and exhaustion. The cause of the profuse
... of the profuse haemorrhage was doubtless chiefly mechanical, the enlarged liver and spleen producing sufficient pressure upon the blood-vessels to impede greatly the return of blood from the upper extremities, and, as Trousseau suggests, there was doubtless extensive rupture of the capillaries of the stomach, caused by their becoming clogged by the larger white globules or leucocytes becoming agglutinated. There were no other conditions or appearances to account satisfactorily for the rapid loss of blood. -» In the report on the progress of physiology published in this journal in January, 1875, an account was given of the experiments which led Goltz to the conclusion that vascular dilatation in any part of the body, following section of the nerve supplying that part, is due to irritation of vaso-dilator nerve fibres, and not, as generally believed, to paralysis of vaso-constrictor fibres. Allusion was made also to the observations of Putzeys and Tarchanoff, pupils of Goltz, who found, in opposition to their teacher, that electrical irritation of the périphérie end of a divided sciatic nerve causes always a contraction of the vessels of the limb, which gives place only after several minutes to a dilatation attributable to exhaustion. In this report an attempt will be made to present briefly the principal results reached by various observers who have recently endeavored to contribute to our knowledge of the vaso-motor mechanism. In the first place it should be mentioned that Vulpian, in his Leçons sur l'appareil vaso-moteur, which appeared shortly after Goltz's paper,1 criticised the statements therein contained, and asserted most emphatically that in numerous experiments on curarized and chloralized dogs, he had always found a contraction and never a dilatation of the vessels of the foot to follow an electrical irritation of the périphérie end of the divided sciatic nerve. Equally decided results were obtained by Eulenburg and Landois 2 in their experiments on rabbits and dogs, the ef-1 Vol. ii., page 480. 2 Virchow's Archiv, lxvi. and lxviii., and Centralblatt f\l =u"\r die med.