The prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer [post]

2019 unpublished
A routine blood examination is one of the most rapid, convenient and inexpensive clinical examinations that can reflect a patient's inflammatory status and other blood conditions, and the prognostic value of routine preoperative blood parameters in MIBC patients is still unclear, so we evaluated the prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer (MIBC) following radical cystectomy (RC). Methods Data on 272 patients with MIBC who underwent RC at our
more » ... derwent RC at our institution were retrospectively collected between March 2006 and August 2018. The median preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and hemoglobin (HGB) values were used as cutoffs to form the low and high NLR, low and high PLR, and low and high HGB groups, respectively. The clinicopathologic characteristics of each group were compared by chi-square and t tests. Kaplan-Meier survival and multivariate Cox regression analyses were used to analyze prognosis. Results The median NLR, PLR and HGB values were 2.48, 115 and 125, respectively. Kaplan-Meier results showed that the high NLR and low HGB groups had poor progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). A high PLR correlated only with poor OS. Multivariate Cox analyses showed that pathologic T4 stage, positive lymph node status and low HGB were independent risk factors for PFS, CSS and OS, and pathologic T3 stage was an independent risk factor for PFS and CSS; however, age was the only independent risk factor for OS. Conclusion Preoperative peripheral blood HGB is an independent risk factor for the prognosis of MIBC patients. These data suggest that HGB may be a useful prognostic marker for MIBC patients undergoing RC.
doi:10.21203/rs.2.17328/v1 fatcat:fx3yhg5cynfoboumlx2em4dyxi