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The existence of cancer cells with stem cell properties (Cancer Stem Cells, CSCs) and their association with tumor resistance and relapse has led to the search for active compounds to eliminate these cells or modulate their stemness in the hope of curing cancer. So far, three classes of drugs that target cancer stemness (Stemness Modulator Drugs) have been identified: i) drugs that selectively eliminate CSCs (stem cell targeting drugs); ii) drugs that decrease stemness (stemness inhibitordoi:10.4081/dts.2012.e10 fatcat:fd5rh62hjvf4zg7rzf3tsel624