Phenolic Compounds from the Roots ofValeriana officinalisvar.latifolia

Peng-Cheng Wang, Xin-Hui Ran, Huai-Rong Luo, Qing-Yun Ma, Yu-Qing Liu, Jun Zhou, You-Xing Zhao
2013 Journal of the Brazilian Chemical Society  
isoferúlico e isovanilina foram isolados a partir das raízes da Valeriana officinalis var. latifolia. Suas estruturas e configurações foram elucidadas com base em métodos espectroscópicos. A atividade inibitória da acetilcolinesterase (AChE) e a atividade intensificada do fator de crescimento neural (NGF) mediada pelo crescimento de neurites em células PC12 pelos compostos isovalerato de 9-di-hidrodesidrodiconiferila e olivil foram avaliadas. A new benzofuran neolignan,
more » ... rodehydrodiconiferyl alcohol 9-isovalerate, along with ten known phenolic compounds, olivil, pinoresinol, 8-hydroxypinoresinol, pinorespiol, 8-hydroxy-7-epipinoresinol, trans-p-hydroxyphenyl-propenoic acid, cis-p-hydroxyphenyl-propenoic acid, ferulic acid, isoferulic acid and isovanillin were isolated from the roots of Valeriana officinalis var. latifolia. Their structures and configurations were elucidated on the basis of spectroscopic methods. The inhibitory activity for acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells of dihydrodehydrodiconiferyl alcohol 9-isovaterate and olivil were evaluated.
doi:10.5935/0103-5053.20130184 fatcat:p4ddf3ubmrewxcm4z2oypoblve