Effects of Astaxanthin on Body and Liver Weight of High-Fat Diet through Regulation of Peroxisome Proliferator-Activated Receptors (PPARs)

Duy Nguyen-Le, My-Tien Ngo, Minh-Tuan Vo, Thuoc Linh Tran, Hieu Tran-Van
2020 International Journal of Life-Sciences Scientific Research  
Astaxanthin (ASTA) is a natural compound well-known for regulating lipid metabolism in the liver, specifically in reducing hepatosteatosis and weight control. In this study, we evaluated the ability to prevent hepatosteatosis and to stabilize body weight of ASTA. Methods: Mice fed a high-fat diet (HFD) were orally given ASTA at a dosage of 30 mg/kg body weight/day in 16 weeks, following eight weeks of ASTA termination. Fat and liver tissues were collected at week 8, 12, 16 and 24 th week of the
more » ... d 24 th week of the trial. RT-qPCR was performed to determine the expression of PPARs in liver tissues. Results: After 24 weeks, unexpectedly, ASTA supplied group (AX) caused excess weight gain since 12 th week, shown in higher average body weight than the HFD group. The result of liver weight was in line with the ratio of liver/body weight within experimental groups as they share the same tendency. However, the liver ratios and hepatosteatosis status were independent, yet even with AX, the AX' liver was still non-steatosis mostly relied on the protection of ASTA. The impacts of ASTA on HFD fed mice also showed effectiveness in preventing hepatosteatosis through down-regulating PPARγ and stabilizing PPARα (liver receptors regulating fat metabolism). Conclusion: This made ASTA a good player for liver lipid homeostasis, but not for weight control. Taken together, ASTA was a potential compound for preventing hepatitis steatosis.
doi:10.21276/ssr-iijls.2020.6.2.4 fatcat:kled3vzqc5h5nlysmytxawgrri