Poster Abstracts

2004 Journal of Nutrition  
that saturated and animal fat may increase endometrial cancer risk whereas evidence was deemed "insufficient" for total fat or dietary cholesterol intake. To support a new version of this report, we conducted systematic literature reviews and metaanalyses on these 4 variables and endometrial cancer risk. We identified 8 case-control and 2 cohort studies with data published in 11 peer-reviewed manuscripts that were suitable for inclusion in the meta-analyses. For total fat intake in a
more » ... cts dose-response meta-analysis, there was a relative risk estimate (RR) of 1.09 [95% confidence interval (CI): 1.01-1.09] for an increase of 10% of energy from fat. For animal fat the summary RR was 1.10 (95% CI: 0.98 -1.25) for an increase of 7 g/1000 kcal. For saturated fat a 7 g/1000 kcal OBJECTIVE: Research is needed to assess exposure in humans and to improve understanding of cancer-preventive functions of diet. Biomarkers, which are specific for individual exposure routes, should be of advantage for this area of research. We have compared different biomarkers in human volunteers. METHODS: Buccal scrapings, blood, and feces were collected from male smokers (20) and nonsmokers (18) during an intervention study with bread enriched with prebiotics with or without antioxidants. Buccal leukocytes and peripheral lymphocytes were isolated by gradient centrifugation. Fecal water (FW) was prepared by ultracentrifugation and incubated with SUPPLEMENT 3522S
doi:10.1093/jn/134.12.3521s fatcat:fkackxr5r5hb3ds6myh52px6fe