Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs

Mi-Hee KIM, Elias GEBRU, Zhi-Qiang CHANG, Jae-Young CHOI, Mi-Hyun HWANG, Eun-Hee KANG, Jong-Hwan LIM, Hyo-In YUN, Seung-Chun PARK
2008 Journal of Veterinary Medical Science  
Clinical pharmacokinetic profiles were investigated following intramuscular (i.m.) administration to pigs with a commercial tylosin-florfenicol combination product at a dose of 2.5 mg/kg tylosin and 5 mg/kg florfenicol or 10 mg/kg tylosin and 20 mg/kg florfenicol. The quantitation limit (QL) of florfenicol was 0.1 µg/ml, the inter-day and intra-day precision (CV%) were both beow 10%. The quantitation limit (QL) of tylosin was 0.05 µg/mL. The pharmacokinetic characteristics after i.m. doses were
more » ... ter i.m. doses were fitted by a one compartment open model. A fourfold decrease in the normal dose of each drug (20 mg/kg to 5 mg/kg for florfenicol, and 10 mg/kg to 2.5 mg/kg for tylosin) resulted in a corresponding two fold decrease in each drug of the maximum plasma concentration (C max ) and the area under curve (AUC) values.
doi:10.1292/jvms.70.99 pmid:18250580 fatcat:xyhtkjzupbhp3kzniaetvrkt2y