The Significance of Serum IGF-I Level as a Predictor of Retinopathy of Prematurity
JOURNAL OF THE KOREAN SOCIETY OF MATERNAL AND CHILD HEALTH
Objectives: Low levels of serum insulin-like growth factor (IGF-I) in preterm infants have been to predict the risk and severity of retinopathy of prematurity (ROP), and other severe perinatal morbidities. This study aimed to find the relation between the level of serum IGF-I and the development and severity of ROP in Korean preterm infants. Methods: A retrospective study was carried out on 73 premature infants who admitted to NICU of Kyungpook National University Hospital from August 2008 to
... om August 2008 to June 2011. We measured the level of serum IGF-I at birth, 14 days, and 21 days. The ophthalmologic examinations were performed once or twice a week, depending on the severity, which was started by the later of 31~33 weeks' postmenstrual age or 4~6 weeks after birth. Results: The level of serum IGF-I at birth is correlated with birth weight. The mean serum IGF-I values at birth is statistically different between appropriate for gestational age infants and small for gestational age, also between infants with and without morbidities, but not statistically different between infants with ROP and infants without ROP. The levels of serum IGF-I at 14 days and 21 days after birth also are not different significantly in infants with ROP. The level of serum IGF-I at birth is not related to the time to recover birth weight, and severity of ROP. Conclusions: The level of serum IGF-1 and early weight gain do not have significance as a predictor of ROP in this study. It needs to perform regular and repetitive ophthalmologic examinations.