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We evaluated the effects of peroxisome proliferator-activated receptor-γ (PPAR-γ ) on the production of tumor necrosis factor-α (TNF-α ) and expression of nuclear factor-κ B (NF-κ B) in stimulated THP-1 cells, a human monocyte cell line. Materials and Methods: We evaluated the cytotoxic effect of 15-Deoxy-Δ 12,14prostaglandin J 2 (15d-PGJ 2 ), one of natural PPAR-γ ligands, using commercial cell proliferation assay. Cells were pretreated with 15d-PGJ 2 and then stimulated withdoi:10.3947/ic.2010.42.5.291 fatcat:el3odlzuqbdknitc4tprjoxxzm