Nd:YAG low-level laser treatment in burning mouth syndrome: a pilot study [post]

2020 unpublished
: Burning mouth syndrome (BMS) is chronic disorder characterized by pain/burning sensation in oral cavity. Nd:YAG low-level laser (LLL) has been used in the treatment of pain reduction. The aim of this study was to assess the effectiveness of LLL verse no power placebo with Nd:YAG in the treatment of patients with BMS in pain/burning, numbness and altered taste. Methods : Forty-two patients with BMS were randomly equally assigned into LLL group and placebo group. The parameters of Nd:YAG
more » ... rs of Nd:YAG irradiation consisted of 100mW power, 3J/cm 2 energy density, 10 Hz, pulse mode and a 1064nm wavelength emission. The placebo group used the same LLL instrument which was switched off. Each patient underwent one laser irradiation session per week for 4 weeks. Clinical assessment of subjective pain/burning, numbness and altered taste was performed using a visual analogue score (VAS) before each irradiation session and one week after last treatment. Results : All of patients (21) was showed significant decreasing of VAS value of pain/burning (ranged from 2% ~100%, mean 52%) after 4-weeks LLL treatment. The improvement of VAS value of numbness in LLL group (ranged from 23% ~100%, mean 61%) was significant from the baseline to the end of LLL treatment. Relief of altered taste was found neither in LLL group nor in placebo group. All patients completed this study and none of them reported adverse effects. Conclusions : Nd:YAG LLL (100mw, 3J/cm 2 , 10 Hz) ) was effective for reduction of pain/burning and numbness in patients with BMS. Background Burning mouth syndrome (BMS) is a chronic disorder characterized by pain/burning sensation in oral cavity [1] . Some patients also suffer numbness, and/or altered taste [2, 3] . The most affected site of oral cavity is tongue, probably company with lips, and hard palate [4, 5] . The prevalence of BMS is 0.1-3.9% [6] and is relatively higher within the group of pre-and post-menopausal women [7] . The possible causal factors are neuropathy, psychology, oral candidiasis, hormonal disorder related with menopause, and nutritional deficiencies [8] . A trigeminal small-fiber sensory neuropathy in BMS was evidenced by diffuse degeneration of epithelial and sub-papillary nerve fibers of anterior two-third of Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
doi:10.21203/rs.2.19620/v1 fatcat:nph6wy257vd7fimdfbqtb62faq