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It is desired for the pharmaceutical intermediate products to form as powder, considering versatility of storage, transportation, and the production schedule adjustment. In this study, aqueous suspension composed of nano-and submicron sized poorly water-soluble drug particles ground by a wet milling was spray dried to produce dry particles. Crystallinity of indomethacin particles was maintained after the spray drying. It was found that mannitol prevented indomethacin particles from cohesiondoi:10.4164/sptj.59.4 fatcat:xgwtyoqzujep5hawuo7oytum6i