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Stochastic modelling of genotypic drug-resistance for human immunodeficiency virus towards long-term combination therapy optimization
2008
Computer applications in the biosciences : CABIOS
Motivation: Several mathematical models have been investigated for the description of viral dynamics in the human body: HIV-1 infection is a particular and interesting scenario, because the virus attacks cells of the immune system that have a role in the antibody production and its high mutation rate permits to escape both the immune response and, in some cases, the drug pressure. The viral genetic evolution is intrinsically a stochastic process, eventually driven by the drug pressure,
doi:10.1093/bioinformatics/btn568
pmid:18977781
fatcat:mozqofkkynd2jj3racxb5emsnu