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AbstractCircular RNAs (circRNAs) are an abundant and conserved class of RNAs with ambiguous functions. Some circRNAs have been shown to be translated through IRES driven cap-independent translation, yet the scope of circRNA translation is unclear because endogenous IRESs are rare. To determine the prevalence and importance of circRNA translation, we screened a random 10-nt library using a cell-based reporter system and identified a large number of AU-rich motifs that are capable of initiatingdoi:10.1101/473207 fatcat:7xsok2vusbhzvmdxqndkvdhyhy