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The effect of octreotide and bromocriptine on expression of a pro-apoptotic Bax protein in rat prolactinoma
Folia Histochemica et Cytobiologica
It is well established that disruption of apoptosis may lead to tumor initiation, progression or metastasis. It is also well documented that many anticancer drugs induce apoptosis. In the earlier studies, the dopamine D2 receptor agonist bromocriptine (BC) and somatostatin analog octreotide (OCT) were found to inhibit the growth of the estrogen-induced rat prolactinoma. Our previous investigations, applying the TUNEL method showed the involvement of the pro-apoptotic effect in the action of BC,pmid:15046398 fatcat:jnhrelnuzvd4dgz5qdxznwhwpe