Preparation and release kinetics of betulinic acid/ CS drug-loaded microspheres

Hao Ran Zhou, Xiao Jiao Fang, Jin Lv, De Xin Wang, J.C.M. Kao, W.-P. Sung
2016 MATEC Web of Conferences  
Chitosan(CS) is the unique alkaline polysaccharide in nature, because of its perfect biocompatibility and degradability, it is widely used in medicine, soft release and control release. The betulinic acid is the derivative of betulin, it has many pharmacological activities, such as anti-inflammatory, antitumor, anti-malaria and anti-HIV. In this paper, the Span-80 was used as emulsifiers, the glutaraldehyde was used as crosslinker. With the method of orthogonal experiment, the preparation
more » ... e preparation technology was optimized. The microspheres were characterized by SEM and its degree of crosslinking, drug-loading rate and encapsulation efficiency were tested at the same time.
doi:10.1051/matecconf/20166303008 fatcat:vkywxneqqja63ojaujjazyokqa