Hippocampal Abnormalities and Seizure Recurrence

J Gordon Millichap
2006 Pediatric Neurology Briefs  
Hippocampal volumetry and T2 relaxometry were performed on 84 consecutive patients (adolescents and adults) with partial epilepsy submitted to antiepileptic drug (AED) withdrawal after at least 2 years of seizure control, in a study at State University of Campinas-UNICAMP, Brazil. Ages ranged from 15 to 76 years (mean, 30 years), and follow-up varied from 5.6 to 11.2 years (mean, 8 years). Hippocampal atrophy was present in 39 (46%) patients; bilateral in 13 and unilateral in 26. Age at time of
more » ... 26. Age at time of scanning, age at seizure onset, and duration of epilepsy were similar in groups with and without HA. Seizure recurrence was more frequent in patients with HA (29/39, 74%) than in those with normal hippocampal volumes (21/45, 47%). Abnormal T2 relaxation times were found in patients with more pronounced HA, and with seizure recurrence. (Cardoso TAM, Coan AC, Kobayashi E et al. Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal. Neurology July (1 of 2) 2006;67:134-136).
doi:10.15844/pedneurbriefs-20-8-7 fatcat:nmdk57kyrndvheqxjdaive7dbe