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Keratoacanthoma (KA) is a common neoplasm and one of variety squamous cell carcinoma (SCC) characterized by rapid growth with potential for tissue damage. Case Presentation: A 64-year-old man presented with hyperkeratotic papules that initially appeared on the dorsum of his hand and slowly progressed to form a large annular plaque along with multiple small keratotic plaques and papules. He was depressed and worried about the appearance and lesions. He had a history of multiple surgery on thedoi:10.21859/focsci-03021418 fatcat:ivn3vk66vvea3i5ogvrt75lmlq