Association of chronic wasting disease susceptibility with prion protein variation in white-tailed deer (Odocoileus virginianus)

Yasuko Ishida, Ting Tian, Adam L. Brandt, Amy C. Kelly, Paul Shelton, Alfred L. Roca, Jan Novakofski, Nohra E. Mateus-Pinilla
Chronic wasting disease (CWD) is caused by prions, infectious proteinaceous particles, PrPCWD. We sequenced the PRNP gene of 2,899 white-tailed deer (WTD) from Illinois and southern Wisconsin, finding 38 haplotypes. Haplotypes A, B, D, E, G and 9 others encoded Q95G96S100N103A123Q226, designated 'PrP variant A.' Haplotype C and 4 other haplotypes encoded PrP 'variant C' (Q95S96S100N103A123Q226). Haplotype F and two other haplotypes encoded PrP 'variant F' (H95G96S100N103A123Q226). The
more » ... 226). The association of CWD with encoded PrP variants was examined in 2,537 tested WTD from counties with CWD. Relative to PrP variant A, CWD susceptibility was lower in deer with PrP variant C (OR = 0.26, p OR = 0.10, p OR = 0.25, p OR = 0.07, p PRNP polymorphisms may be a useful tool in CWD management.
doi:10.6084/m9.figshare.12851738.v1 fatcat:gytim4nig5es5oh3m7co36e64y