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Background: Prostate cancer stem-like cells (PCSCs) likely participate in tumor progression and recurrence, and demonstrate resistance to chemotherapy. The Notch pathway plays a role in the maintenance of the stemness in PCSCs. This study aimed to investigate the efficacy of Notch signaling inhibition as an adjuvant to docetaxel (DOX) in PCSCs.Methods: PCSCs derived from PC-3 cell line were examined for Notch-1 expression. The effect of Notch inhibition on response to DOX was evaluated in PCSCsdoi:10.21203/rs.3.rs-17013/v2 fatcat:cci3mdjmkveqzgaw5scjdurfui